Synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2008
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Resumo |
A simple synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester is reported.The preparation Of Such compounds is based in a straightforward methodology, which involves the Diels-Alder reaction of protoporphyrin-IX dimethyl ester with maleic anhydride followed by addition of nucleophilic species to the initially formed cycloadducts, a transformation, which is highly regioselective. Preliminary photophysical studies with the new compounds show that they meet adequate features for PDT applications. (c) 2008 Elsevier Ltd. All rights reserved. CNPq[200414/2006-2] |
Identificador |
TETRAHEDRON, v.64, n.37, p.8709-8715, 2008 0040-4020 http://producao.usp.br/handle/BDPI/20738 10.1016/j.tet.2008.06.103 |
Idioma(s) |
eng |
Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
Relação |
Tetrahedron |
Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
Palavras-Chave | #DIELS-ALDER REACTIONS #PHOTODYNAMIC THERAPY #SINGLET OXYGEN #BENZOPORPHYRIN DERIVATIVES #UPDATE 2006 #PHOTOSENSITIZERS #SENSITIZERS #CANCER #Chemistry, Organic |
Tipo |
article original article publishedVersion |