Synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester


Autoria(s): OLIVEIRA, Kleber T. de; SILVA, Artur M. S.; TOME, Auglisto C.; NEVES, Maria G. P. M. S.; NERI, Claudio R.; GARCIA, Vinicius S.; SERRA, Osvaldo A.; IAMAMOTO, Yassuko; CAVALEIRO, Jose A. S.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

A simple synthesis of new amphiphilic chlorin derivatives from protoporphyrin-IX dimethyl ester is reported.The preparation Of Such compounds is based in a straightforward methodology, which involves the Diels-Alder reaction of protoporphyrin-IX dimethyl ester with maleic anhydride followed by addition of nucleophilic species to the initially formed cycloadducts, a transformation, which is highly regioselective. Preliminary photophysical studies with the new compounds show that they meet adequate features for PDT applications. (c) 2008 Elsevier Ltd. All rights reserved.

CNPq[200414/2006-2]

Identificador

TETRAHEDRON, v.64, n.37, p.8709-8715, 2008

0040-4020

http://producao.usp.br/handle/BDPI/20738

10.1016/j.tet.2008.06.103

http://dx.doi.org/10.1016/j.tet.2008.06.103

Idioma(s)

eng

Publicador

PERGAMON-ELSEVIER SCIENCE LTD

Relação

Tetrahedron

Direitos

restrictedAccess

Copyright PERGAMON-ELSEVIER SCIENCE LTD

Palavras-Chave #DIELS-ALDER REACTIONS #PHOTODYNAMIC THERAPY #SINGLET OXYGEN #BENZOPORPHYRIN DERIVATIVES #UPDATE 2006 #PHOTOSENSITIZERS #SENSITIZERS #CANCER #Chemistry, Organic
Tipo

article

original article

publishedVersion