The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2009
|
| Resumo |
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity IC(50) 0.01 mu M). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 mu M) than other alkaloids tested. (C) 2009 Elsevier GmbH. All rights reserved. FUNDECT-Brazil CNPq |
| Identificador |
PHYTOMEDICINE, v.16, n.11, p.1059-1063, 2009 0944-7113 http://producao.usp.br/handle/BDPI/20358 10.1016/j.phymed.2009.03.019 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Relação |
Phytomedicine |
| Direitos |
restrictedAccess Copyright ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Palavras-Chave | #Duguetia furfuracea #Annonaceae #Antitumoral activity #Antileishmanial #Trypanocidal #Alkaloids #APORPHINE ALKALOIDS #NATURAL-PRODUCTS #ANNONACEAE #INHIBITOR #GROWTH #DRUGS #Plant Sciences #Chemistry, Medicinal #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
