Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.


Autoria(s): GALLO, Margareth B. C.; MARQUES, Anna Sylvia F.; VIEIRA, Paulo C.; SILVA, Maria Fitima das G. F. da; FERNANDES, Joao B.; SILVA, Marcio; GUIDO, Rafael V.; OLIVA, Glaucius; THIEMANN, Otavio H.; ALBUQUERQUE, Sergio; FAIRLAMB, Alan H.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

Identificador

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.63, n.5/Jun, p.371-382, 2008

0939-5075

http://producao.usp.br/handle/BDPI/20285

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000257377200011&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

VERLAG Z NATURFORSCH

Relação

Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences

Direitos

restrictedAccess

Copyright VERLAG Z NATURFORSCH

Palavras-Chave #myrtaceae #Trypanosoma #Leishmania #PLANT-EXTRACTS #CONSTITUENTS #IDENTIFICATION #METABOLISM #MYRTACEAE #TRYPANOTHIONE #TRYPANOSOMES #FLAVONOIDS #FEATURES #Biochemistry & Molecular Biology #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion