Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2008
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Resumo |
Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays. |
Identificador |
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.63, n.5/Jun, p.371-382, 2008 0939-5075 |
Idioma(s) |
eng |
Publicador |
VERLAG Z NATURFORSCH |
Relação |
Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences |
Direitos |
restrictedAccess Copyright VERLAG Z NATURFORSCH |
Palavras-Chave | #myrtaceae #Trypanosoma #Leishmania #PLANT-EXTRACTS #CONSTITUENTS #IDENTIFICATION #METABOLISM #MYRTACEAE #TRYPANOTHIONE #TRYPANOSOMES #FLAVONOIDS #FEATURES #Biochemistry & Molecular Biology #Pharmacology & Pharmacy |
Tipo |
article original article publishedVersion |