Candida albicans and Candida tropicalis in Oral Candidosis: Quantitative Analysis, Exoenzyme Activity, and Antifungal Drug Sensitivity


Autoria(s): COSTA, Karen Regina Carim da; FERREIRA, Joseane Cristina; KOMESU, Marilena Chinali; CANDIDO, Regina Celia
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Candida albicans and C. tropicalis obtained from whole saliva of patients presenting signs of oral candidosis were assayed for quantification of colony forming units, exoenzyme activity (phospholipase and proteinase) and antifungal drug sensitivity (amphotericin B, fluconazole and itraconazole) by the reference method of the Clinical and Laboratory Standards Institute. The number of colony forming units per milliliter varied according to the Candida species involved and whether a single or mixed infection was present. Proteinase activity was observed in both C. albicans and C. tropicalis, but phospholipase activity was noted only in C. albicans. In vitro resistance to antifungals was verified in both species, but C. tropicalis appears to be more resistant to the tested antifungals than C. albicans.

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)

Identificador

MYCOPATHOLOGIA, v.167, n.2, p.73-79, 2009

0301-486X

http://producao.usp.br/handle/BDPI/20239

10.1007/s11046-008-9154-8

http://dx.doi.org/10.1007/s11046-008-9154-8

Idioma(s)

eng

Publicador

SPRINGER

Relação

Mycopathologia

Direitos

restrictedAccess

Copyright SPRINGER

Palavras-Chave #Antifungal drug sensitivity #Candida albicans #Candida tropicalis #Exoenzyme activity #Oral candidosis #Quantitative analysis #SECRETED ASPARTIC PROTEINASE #PHOSPHOLIPASE #VIRULENCE #PATHOGENICITY #RESISTANCE #STRAINS #Mycology
Tipo

article

original article

publishedVersion