In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
Dimethylaminoethanol (DMAE) has been used in anti-aging formulations but few scientifically based data address its efficacy. The aim of this study was to evaluate the effects of DMAE-based formulations on hairless mice and human skin. Formulations containing with or without DMAE were applied to the dorsum of hairless mice. Histopathological and histometric evaluations were carried out after seven days. Formulations were also applied to the ventral forearm and the lateral periocular area of human volunteers. Stratum corneum water content and skin mechanical properties were analyzed using Corneometer and Cutometer, before and after a single and repeated application. Histometric evaluations showed that formulations with or without DMAE increased the viable epidermis thickness, but only the DMAE-supplemented formulation led to increased dermal thickness. DMAE also induced increase in collagen fiber thickness, which was observed in the histopathological study. After the single and the 8-week period application on human skin, formulations with and without DMAE enhanced the stratum corneum water content in the forearm skin. Mechanical properties were not significantly modified. So, we can suggest that DMAE action is related to its effects on the dermis as observed in the histopathological and histometric studies and showed hydration effects on skin. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES) |
Identificador |
PHARMAZIE, v.64, n.12, p.818-822, 2009 0031-7144 http://producao.usp.br/handle/BDPI/20171 10.1691/ph.2009.9636 |
Idioma(s) |
eng |
Publicador |
GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH |
Relação |
Pharmazie |
Direitos |
closedAccess Copyright GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH |
Palavras-Chave | #HORMONE REPLACEMENT THERAPY #COLLAGEN CONTENT #POLYSACCHARIDE #THICKNESS #FUCOSE #DEANOL #Chemistry, Medicinal #Chemistry, Multidisciplinary #Pharmacology & Pharmacy |
Tipo |
article original article publishedVersion |