In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation


Autoria(s): TADINI, K. A.; CAMPOS, P. M. B. G. Maia
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Dimethylaminoethanol (DMAE) has been used in anti-aging formulations but few scientifically based data address its efficacy. The aim of this study was to evaluate the effects of DMAE-based formulations on hairless mice and human skin. Formulations containing with or without DMAE were applied to the dorsum of hairless mice. Histopathological and histometric evaluations were carried out after seven days. Formulations were also applied to the ventral forearm and the lateral periocular area of human volunteers. Stratum corneum water content and skin mechanical properties were analyzed using Corneometer and Cutometer, before and after a single and repeated application. Histometric evaluations showed that formulations with or without DMAE increased the viable epidermis thickness, but only the DMAE-supplemented formulation led to increased dermal thickness. DMAE also induced increase in collagen fiber thickness, which was observed in the histopathological study. After the single and the 8-week period application on human skin, formulations with and without DMAE enhanced the stratum corneum water content in the forearm skin. Mechanical properties were not significantly modified. So, we can suggest that DMAE action is related to its effects on the dermis as observed in the histopathological and histometric studies and showed hydration effects on skin.

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)

Identificador

PHARMAZIE, v.64, n.12, p.818-822, 2009

0031-7144

http://producao.usp.br/handle/BDPI/20171

10.1691/ph.2009.9636

http://dx.doi.org/10.1691/ph.2009.9636

Idioma(s)

eng

Publicador

GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH

Relação

Pharmazie

Direitos

closedAccess

Copyright GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH

Palavras-Chave #HORMONE REPLACEMENT THERAPY #COLLAGEN CONTENT #POLYSACCHARIDE #THICKNESS #FUCOSE #DEANOL #Chemistry, Medicinal #Chemistry, Multidisciplinary #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion