In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2009
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| Resumo |
Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani. with an IC(50) value of 45 mu g/mL. while GPE presented an IC(50) value of 49 mu g/mL Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC(50) values of 3.7 mu g/mL and 7.0 mu g/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC(50) values (about 20 mu g/mL), while Hautriwaic acid lactone led to an IC(50) value of 0.8 mu g/mL (D6 clone). (C) 2009 Elsevier B.V. All rights reserved. FAPESP[06/60132-4: 01/14209-7] CAPES[PDEE/BEX 0387/04-5] |
| Identificador |
FITOTERAPIA, v.80, n.8, p.478-482, 2009 0367-326X http://producao.usp.br/handle/BDPI/20170 10.1016/j.fitote.2009.06.007 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV |
| Relação |
Fitoterapia |
| Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #Baccharis dracunculifolia #Brazilian green propolis #Leishmania donovani #Plasmodium falciparum #Ursolic acid #Hautriwaic acid lactone #BRAZILIAN GREEN PROPOLIS #TETRAHYDROFURAN LIGNANS #NECTANDRA-MEGAPOTAMICA #TRYPANOCIDAL ACTIVITY #DERIVATIVES #DITERPENES #EXTRACT #VIVO #Chemistry, Medicinal #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
