Photoprotective potential of emulsions formulated with Buriti oil (Mauritia flexuosa) against UV irradiation on keratinocytes and fibroblasts cell lines


Autoria(s): ZANATTA, C. F.; MITJANS, M.; URGATONDO, V.; ROCHA-FILHO, P. A.; VINARDELL, M. P.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

Considering the belief that natural lipids are safer for topical applications and that carotenoids are able to protect cells against photooxidative damage, we have investigated whether topical creams and lotions, produced with Buriti oil and commercial surfactants, can exert photoprotective effect against UVA and UVB irradiation on keratinocytes and fibroblasts. Cell treatment was divided into two steps, prior and after exposition to 30 min of UVA plus UVB radiation or to 60 min of UVA radiation. Emulsions prepared with ethoxylated fatty alcohols as surfactants and containing alpha-tocopherol caused phototoxic damage to the cells, especially when applied prior to UV exposure. Damage reported was due to prooxidant activity and phototoxic effect of the surfactant. Emulsions prepared with Sorbitan Monooleate and PEG-40 castor oil and containing panthenol as active ingredient, were able to reduce the damages caused by radiation when compared to non-treated cells. When the two cell lines used in the study were compared, keratinocytes showed an increase in cell viability higher than fibroblasts. The Buriti oil emulsions could be considered potential vehicles to transport antioxidants precursors and also be used as adjuvant in sun protection, especially in after sun formulations. (C) 2009 Elsevier Ltd. All rights reserved.

CAPES (Brazil)

Fundacio Bosch i Gimpera, Universitat de Barcelona, Spain[501]

Identificador

FOOD AND CHEMICAL TOXICOLOGY, v.48, n.1, p.70-75, 2010

0278-6915

http://producao.usp.br/handle/BDPI/20160

10.1016/j.fct.2009.09.017

http://dx.doi.org/10.1016/j.fct.2009.09.017

Idioma(s)

eng

Publicador

PERGAMON-ELSEVIER SCIENCE LTD

Relação

Food and Chemical Toxicology

Direitos

restrictedAccess

Copyright PERGAMON-ELSEVIER SCIENCE LTD

Palavras-Chave #Buriti oil #Emulsion #UV protection #Skin irritation #Cell culture #HUMAN SKIN FIBROBLASTS #BETA-CAROTENE #VITAMIN-C #NATURAL LIPIDS #CYTOTOXICITY #DAMAGE #RADIATION #ACID #ULTRAVIOLET #EXPRESSION #Food Science & Technology #Toxicology
Tipo

article

original article

publishedVersion