Chitosan microparticles for sustaining the topical delivery of minoxidil sulphate


Autoria(s): GELFUSO, Guilherme Martins; GRATIERI, Tais; SIMAO, Patricia Sper; FREITAS, Luis Alexandre Pedro de; LOPEZ, Renata Fonseca Vianna
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

Given the hypothesis that microparticles can penetrate the skin barrier along the transfollicular route, this work aimed to obtain and characterise chitosan microparticles loaded with minoxidil sulphate (MXS) and to study their ability to sustain the release of the drug, attempting a further application utilising them in a targeted delivery system for the topical treatment of alopecia. Chitosan microparticles, containing different proportions of MXS/polymer, were prepared by spray drying and were characterised by yield, encapsulation efficiency, size and morphology. Microparticles selected for further studies showed high encapsulation efficiency (similar to 82%), a mean diameter of 3.0 mu m and a spherical morphology without porosities. When suspended in an ethanol/water solution, chitosan microparticles underwent instantaneous swelling, increasing their mean diameter by 90%. Release studies revealed that the chitosan microparticles were able to sustain about three times the release rate of MXS. This feature, combined with suitable size, confers to these microparticles the potential to target and improve topical therapy of alopecia with minoxidil.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil

Identificador

JOURNAL OF MICROENCAPSULATION, v.28, n.7, p.650-658, 2011

0265-2048

http://producao.usp.br/handle/BDPI/20123

10.3109/02652048.2011.604435

http://dx.doi.org/10.3109/02652048.2011.604435

Idioma(s)

eng

Publicador

INFORMA HEALTHCARE

Relação

Journal of Microencapsulation

Direitos

restrictedAccess

Copyright INFORMA HEALTHCARE

Palavras-Chave #microparticles #chitosan #minoxidil sulphate #follicular delivery #alopecia #topical delivery #TRANSDERMAL DELIVERY #DRUG-DELIVERY #NANOPARTICLES #MICROSPHERES #SKIN #PENETRATION #PARAMETERS #CARRIER #Chemistry, Applied #Engineering, Chemical #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion