Antileishmanial Sesquiterpenes from the Brazilian Red Alga Laurencia dendroidea
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity. CAPES FINEP[3175/06] CNPQ |
| Identificador |
PLANTA MEDICA, v.77, n.7, p.733-735, 2011 0032-0943 http://producao.usp.br/handle/BDPI/19968 10.1055/s-0030-1250526 |
| Idioma(s) |
eng |
| Publicador |
GEORG THIEME VERLAG KG |
| Relação |
Planta Medica |
| Direitos |
restrictedAccess Copyright GEORG THIEME VERLAG KG |
| Palavras-Chave | #antileishmanial activity #halogenated sesquiterpenes #Laurencia dendroidea J. Agardh #Rhodomelaceae #Leishmania amazonensis Lainson & Shaw #TROPICAL MARINE-ALGAE #CHAMIGRANE METABOLITES #ANTIBACTERIAL #SPONGE #LEISHMANIA #OBTUSA #Plant Sciences #Chemistry, Medicinal #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
