Prospects in Lyophilization of Bovine Pericardium


Autoria(s): LEIRNER, Adolfo A.; TATTINI JR., Virgilio; PITOMBO, Ronaldo N. M.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Almost 30 years after the introduction of heart valve prostheses patients worldwide are benefiting from the implant of these devices. Among the various types of heart valves, the ones made of treated bovine pericardium have become a frequently used replacement of the heart`s native valve. Lyophilization, also known as freeze-drying, is an extremely useful technique for tissue storage for surgical applications. This article gives a brief overview on the current bovine pericardium lyophilization development, including the chemical modification to improve physical-chemical characteristics and the advanced technologies used to guarantee a high-quality product. It was shown that lyophilization process can be successfully applied as a method of bovine pericardium preservation and also as a technological tool to prepare new materials obtained by chemical modification of native tissues.

Identificador

ARTIFICIAL ORGANS, v.33, n.3, p.221-229, 2009

0160-564X

http://producao.usp.br/handle/BDPI/19793

10.1111/j.1525-1594.2009.00712.x

http://dx.doi.org/10.1111/j.1525-1594.2009.00712.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL PUBLISHING, INC

Relação

Artificial Organs

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL PUBLISHING, INC

Palavras-Chave #Bovine pericardium #Heart valves #Freeze-drying #Raman spectroscopy #Thermal analysis #DIFFERENTIAL SCANNING CALORIMETRY #BIOPROSTHETIC HEART-VALVE #EPOXY COMPOUNDS #SHRINKAGE TEMPERATURE #COLLAGEN #TISSUE #GLUTARALDEHYDE #CALCIFICATION #RESOLUTION #HYDRATION #Engineering, Biomedical #Transplantation
Tipo

article

original article

publishedVersion