Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new compounds were synthesized in moderate to good yields. The click chemistry reaction can be effected by using sodium ascorbate and CuSO(4) center dot 5H(2)O as catalyst in toluene-H(2)O at room temperature. FAPESP[07/59404-2] CNPq[300613/2007-5] ANII[FCE252-2009] |
| Identificador |
MOLECULAR DIVERSITY, v.15, n.1, Special Issue, p.163-172, 2011 1381-1991 http://producao.usp.br/handle/BDPI/19655 10.1007/s11030-010-9237-6 |
| Idioma(s) |
eng |
| Publicador |
SPRINGER |
| Relação |
Molecular Diversity |
| Direitos |
closedAccess Copyright SPRINGER |
| Palavras-Chave | #Organotrifloroborates #Suzuki-Miyaura #Click chemistry #Chemoenzymatic synthesis #AZIDE CYCLOADDITION REACTIONS #HUISGEN CYCLOADDITION #DERIVATIVES #LIGATION #ALKYNES #Biochemistry & Molecular Biology #Chemistry, Applied #Chemistry, Medicinal #Chemistry, Multidisciplinary |
| Tipo |
article original article publishedVersion |
