Cyclophosphamide levels in sites of preparation and administration of antineoplastic drugs


Autoria(s): MARTINS, Isarita; APOSTOLI, Pietro; ROSA, Henrique V. Della
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2008

Resumo

The extensive use of antineoplastic agents in chemotherapy may be at risk to health care workers involved in the preparation and administration of these drugs. In this study cyclophosphamide, a drug classified as a human carcinogen, was quantified by adapting a previous analytical method using gas chromatography coupled to mass spectrometry (GC-MS) after solid phase extraction with diatomaceous earth. The drug was measured by analysis in surfaces (wipe samples) and gloves, collected from four different hospitals, before and after the practice of cleaning procedures, and the use of a closed-system device for the preparation and administration. Validation results were satisfactory and cyclophosphamide levels ranging from below the quantification limit to 141000 ng. Our findings demonstrated that surfaces and materials contamination was found in all hospitals during the traditional open technique for preparation and administration of cyclophosphamide and a significant reduction in contamination when a closed-system device was used. However, some values were considered unexpected, especially those obtained from samples collected after the cleaning surfaces.

Identificador

LATIN AMERICAN JOURNAL OF PHARMACY, v.27, n.2, p.217-223, 2008

0326-2383

http://producao.usp.br/handle/BDPI/19549

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000257703700009&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES

Relação

Latin American Journal of Pharmacy

Direitos

restrictedAccess

Copyright COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES

Palavras-Chave #cyclophosphamide #occupational exposure #GC-MS #SURFACE CONTAMINATION #OCCUPATIONAL-EXPOSURE #MASS-SPECTROMETRY #CLOSED-SYSTEM #AGENTS #IFOSFAMIDE #VALIDATION #WORKERS #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion