Identification of a bioactive compound isolated from Brazilian propolis type 6
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
18/10/2012
18/10/2012
2009
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| Resumo |
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50) = 0.1756 mu M), strong antimicrobial activity (MIC range-0.73-6.6 mu g/mL; MBC range-2.92-106 mu g/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. (C) 2009 Elsevier Ltd. All rights reserved. CNPq[131758/2006-3] CNPq[302222/2008-1] FAPESP[2004/08635-6] FAPEMIG[EDT-240/05] |
| Identificador |
BIOORGANIC & MEDICINAL CHEMISTRY, v.17, n.14, p.5332-5335, 2009 0968-0896 http://producao.usp.br/handle/BDPI/18865 10.1016/j.bmc.2009.04.066 |
| Idioma(s) |
eng |
| Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
| Relação |
Bioorganic & Medicinal Chemistry |
| Direitos |
closedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
| Palavras-Chave | #Prenylated benzophenone hyperibone A #Brazilian propolis #Biological activity #ANTIBACTERIAL ACTIVITY #MUTANS STREPTOCOCCI #POLYISOPRENYLATED BENZOPHENONE #BIOLOGICAL-ACTIVITY #CUBAN PROPOLIS #APIS-MELLIFERA #CLUSIA-ROSEA #DERIVATIVES #CONSTITUENTS #NEMOROSONE #Biochemistry & Molecular Biology #Chemistry, Medicinal #Chemistry, Organic |
| Tipo |
article original article publishedVersion |
