Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training


Autoria(s): Gualano, Bruno; Novaes, Rafael Batista; Artioli, Guilherme Giannini; Freire, T. O.; Coelho, D. F.; Scagliusi, F. B.; Rogeri, P. S.; Roschel, Hamilton; Ugrinowitsch, Carlos; Lancha Junior, Antonio Herbert
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

18/10/2012

18/10/2012

2008

Resumo

Recent findings have indicated that creatine supplementation may affect glucose metabolism. This study aimed to examine the effects of creatine supplementation, combined with aerobic training, on glucose tolerance in sedentary healthy male. Subjects (n = 22) were randomly divided in two groups and were allocated to receive treatment with either creatine (CT) (similar to 10g .day over three months) or placebo (PT) (dextrose). Administration of treatments was double blind. Both groups underwent moderate aerobic training. An oral glucose tolerance test (OGTT) was performed and both fasting plasma insulin and the homeostasis model assessment (HOMA) index were assessed at the start, and after four, eight and twelve weeks. CT demonstrated significant decrease in OGTT area under the curve compared to PT (P = 0.034). There were no differences between groups or over time in fasting insulin or HOMA. The results suggest that creatine supplementation, combined with aerobic training, can improve glucose tolerance but does not affect insulin sensitivity, and may warrant further investigation with diabetic subjects.

Identificador

AMINO ACIDS, v.34, n.2, p.245-250, 2008

0939-4451

http://producao.usp.br/handle/BDPI/17442

10.1007/s00726-007-0508-1

http://dx.doi.org/10.1007/s00726-007-0508-1

Idioma(s)

eng

Publicador

SPRINGER

Relação

Amino Acids

Direitos

restrictedAccess

Copyright SPRINGER

Palavras-Chave #creatine #glucose tolerance #insulin sensitivity #aerobic training #HUMAN SKELETAL-MUSCLE #HOMEOSTASIS #ACCUMULATION #RESISTANCE #EXPRESSION #SECRETION #INGESTION #EXERCISE #HUMANS #MODEL #Biochemistry & Molecular Biology
Tipo

article

original article

publishedVersion