Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/04/2012
19/04/2012
2011
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| Resumo |
A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes. National Institutes of Health (NIH)[CA126937] National Institutes of Health (NIH)[CA152194] CNPq Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) FAPESP |
| Identificador |
ORGANIC & BIOMOLECULAR CHEMISTRY, v.9, n.5, p.1347-1351, 2011 1477-0520 http://producao.usp.br/handle/BDPI/16773 10.1039/c0ob01050b |
| Idioma(s) |
eng |
| Publicador |
ROYAL SOC CHEMISTRY |
| Relação |
Organic & Biomolecular Chemistry |
| Direitos |
closedAccess Copyright ROYAL SOC CHEMISTRY |
| Palavras-Chave | #GLUTATHIONE-PEROXIDASE MIMICS #SELENIUM-COMPOUNDS #THIOREDOXIN REDUCTASE #CANCER PREVENTION #IMMUNOMODULATOR AS101 #DIORGANYL TELLURIDES #ANTIOXIDANT ACTIVITY #MICE #MECHANISMS #CYSTEINE #Chemistry, Organic |
| Tipo |
article original article publishedVersion |
