Construct and Compare Gene Coexpression Networks with DAPfinder and DAPview
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/04/2012
19/04/2012
2011
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Resumo |
Background: DAPfinder and DAPview are novel BRB-ArrayTools plug-ins to construct gene coexpression networks and identify significant differences in pairwise gene-gene coexpression between two phenotypes. Results: Each significant difference in gene-gene association represents a Differentially Associated Pair (DAP). Our tools include several choices of filtering methods, gene-gene association metrics, statistical testing methods and multiple comparison adjustments. Network results are easily displayed in Cytoscape. Analyses of glioma experiments and microarray simulations demonstrate the utility of these tools. Conclusions: DAPfinder is a new friendly-user tool for reconstruction and comparison of biological networks. Department of Intramural Research (DIR) Office of the Director (OD) at NIAID, NIH |
Identificador |
BMC BIOINFORMATICS, LONDON, v.12, 2011 1471-2105 http://producao.usp.br/handle/BDPI/16676 10.1186/1471-2105-12-286 |
Idioma(s) |
eng |
Publicador |
BIOMED CENTRAL LTD LONDON |
Relação |
BMC Bioinformatics |
Direitos |
openAccess Copyright BIOMED CENTRAL LTD |
Palavras-Chave | #FALSE DISCOVERY RATE #RECEPTOR GENE #BRAIN-TUMORS #EXPRESSION #GROWTH #CANCER #AMPLIFICATION #DEPENDENCY #PROFILES #EGFR #Biochemical Research Methods #Biotechnology & Applied Microbiology #Mathematical & Computational Biology |
Tipo |
article original article publishedVersion |