Tetraploidization in Wilms tumor in an infant
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
18/04/2012
18/04/2012
2010
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Resumo |
Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones of tumor cells were observed, with DNA content varying from diploid to near-tetraploid complements. The genetic events involved in the acquisition of aneuploidy in Wilms tumor remain unclear. We hypothesize that initial tetraploidization caused aberrant cell division, leading to abnormal chromosomal segregation, cell transformation and tumorigenesis. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[06/04827-3] Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[07/54236-4] |
Identificador |
GENETICS AND MOLECULAR RESEARCH, v.9, n.3, p.1577-1581, 2010 1676-5680 http://producao.usp.br/handle/BDPI/15370 10.4238/vol9-3gmr880 |
Idioma(s) |
eng |
Publicador |
FUNPEC-EDITORA |
Relação |
Genetics and Molecular Research |
Direitos |
openAccess Copyright FUNPEC-EDITORA |
Palavras-Chave | #Wilms tumor #Cancer biology #Cytogenetics #Tumor biology #DNA-PLOIDY #ANEUPLOIDY #CANCER #Biochemistry & Molecular Biology #Genetics & Heredity |
Tipo |
article original article publishedVersion |