Tetraploidization in Wilms tumor in an infant


Autoria(s): VALERA, E. T.; BRASSESCO, M. S.; SCRIDELI, C. A.; TONE, L. G.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

18/04/2012

18/04/2012

2010

Resumo

Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones of tumor cells were observed, with DNA content varying from diploid to near-tetraploid complements. The genetic events involved in the acquisition of aneuploidy in Wilms tumor remain unclear. We hypothesize that initial tetraploidization caused aberrant cell division, leading to abnormal chromosomal segregation, cell transformation and tumorigenesis.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[06/04827-3]

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[07/54236-4]

Identificador

GENETICS AND MOLECULAR RESEARCH, v.9, n.3, p.1577-1581, 2010

1676-5680

http://producao.usp.br/handle/BDPI/15370

10.4238/vol9-3gmr880

http://dx.doi.org/10.4238/vol9-3gmr880

Idioma(s)

eng

Publicador

FUNPEC-EDITORA

Relação

Genetics and Molecular Research

Direitos

openAccess

Copyright FUNPEC-EDITORA

Palavras-Chave #Wilms tumor #Cancer biology #Cytogenetics #Tumor biology #DNA-PLOIDY #ANEUPLOIDY #CANCER #Biochemistry & Molecular Biology #Genetics & Heredity
Tipo

article

original article

publishedVersion