Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women


Autoria(s): SANTOS, Raquel Alves dos; TEIXEIRA, Ana Claudia; MAYORANO, Monica Beatriz; CARRARA, Helio Humberto Angotti; ANDRADE, Jurandyr Moreira de; TAKAHASHI, Catarina Satie
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

18/04/2012

18/04/2012

2011

Resumo

In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of the COMT gene. We also observed that CYP17 and CYP1A1 polymorphisms can modify the risk to BC depending on the menopause status. We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC. These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups.

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq[400887/2005]

Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq[3473493/2004-7]

Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES

Identificador

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011

1110-7243

http://producao.usp.br/handle/BDPI/15341

10.1155/2011/571784

http://dx.doi.org/10.1155/2011/571784

Idioma(s)

eng

Publicador

HINDAWI PUBLISHING CORPORATION

Relação

Journal of Biomedicine and Biotechnology

Direitos

openAccess

Copyright HINDAWI PUBLISHING CORPORATION

Palavras-Chave #PERIPHERAL-BLOOD LYMPHOCYTES #CATECHOL-O-METHYLTRANSFERASE #DNA-DAMAGE #MICRONUCLEUS FREQUENCY #MOLECULAR EPIDEMIOLOGY #COMET ASSAY #RISK #POLYMORPHISMS #CYP1A1 #LEVEL #Biotechnology & Applied Microbiology #Medicine, Research & Experimental
Tipo

article

original article

publishedVersion