Variability in Estrogen-Metabolizing Genes and Their Association with Genomic Instability in Untreated Breast Cancer Patients and Healthy Women
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
18/04/2012
18/04/2012
2011
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Resumo |
In the present study, we investigated the relationship between polymorphisms in the estrogen-metabolizing genes CYP17, CYP1B1, CYP1A1, and COMT and genomic instability in the peripheral blood lymphocytes of 62 BC patients and 62 controls considering that increased or prolonged exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. Our data demonstrated increased genomic instability in BC patients and that individuals with higher frequencies of MN exhibited higher risk to BC when belonging Val/Met genotype of the COMT gene. We also observed that CYP17 and CYP1A1 polymorphisms can modify the risk to BC depending on the menopause status. We can conclude that the genetic background in estrogen metabolism pathway can modulate chromosome damage in healthy controls and patients and thereby influence the risk to BC. These findings suggest the importance to ally biomarkers of susceptibility and effects to estimate risk groups. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq[400887/2005] Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq[3473493/2004-7] Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES |
Identificador |
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011 1110-7243 http://producao.usp.br/handle/BDPI/15341 10.1155/2011/571784 |
Idioma(s) |
eng |
Publicador |
HINDAWI PUBLISHING CORPORATION |
Relação |
Journal of Biomedicine and Biotechnology |
Direitos |
openAccess Copyright HINDAWI PUBLISHING CORPORATION |
Palavras-Chave | #PERIPHERAL-BLOOD LYMPHOCYTES #CATECHOL-O-METHYLTRANSFERASE #DNA-DAMAGE #MICRONUCLEUS FREQUENCY #MOLECULAR EPIDEMIOLOGY #COMET ASSAY #RISK #POLYMORPHISMS #CYP1A1 #LEVEL #Biotechnology & Applied Microbiology #Medicine, Research & Experimental |
Tipo |
article original article publishedVersion |