Chitosan Nanoparticles Loaded The Herbicide Paraquat: The Influence Of The Aquatic Humic Substances On The Colloidal Stability And Toxicity.


Autoria(s): Grillo, Renato; Clemente, Zaira; Oliveira, Jhones Luis de; Campos, Estefânia Vangelie Ramos; Chalupe, Victor C; Jonsson, Claudio M; Lima, Renata de; Sanches, Gabriela; Nishisaka, Caroline S; Rosa, André H; Oehlke, Kathleen; Greiner, Ralf; Fraceto, Leonardo F
Contribuinte(s)

UNIVERSIDADE DE ESTADUAL DE CAMPINAS

Data(s)

01/04/2015

27/11/2015

27/11/2015

Resumo

Polymeric nanoparticles have been developed for several applications, among them as carrier system of pesticides. However, few studies have investigated the fate of these materials in the environment in relation to colloidal stability and toxicity. In nature, humic substances are the main agents responsible for complexation with metals and organic compounds, as well as responsible for the dynamics of these nanoparticles in aquatic and terrestrial environments. In this context, the evaluation of the influence of aquatic humic substances (AHS) on the colloidal stability and toxicity of polymeric nanoparticles of chitosan/tripolyphosphate with or without paraquat was performed. In this study, the nanoparticles were prepared by the ionic gelation method and characterized by size distribution measurements (DLS and NTA), zeta potential, infrared and fluorescence spectroscopy. Allium cepa genotoxicity studies and ecotoxicity assays with the alga Pseudokirchneriella subcapitata were used to investigate the effect of aquatic humic substances (AHS) on the toxicity of this delivery system. No changes were observed in the physical-chemical stability of the nanoparticles due to the presence of AHS using DLS and NTA techniques. However some evidence of interaction between the nanoparticles and AHS was observed by infrared and fluorescence spectroscopies. The ecotoxicity and genotoxicity assays showed that humic substances can decrease the toxic effects of nanoparticles containing paraquat. These results are interesting because they are important for understanding the interaction of these nanostructured carrier systems with species present in aquatic ecosystems such as humic substances, and in this way, opening new perspectives for studies on the dynamics of these carrier systems in the ecosystem.

286

562-72

Identificador

Journal Of Hazardous Materials. v. 286, p. 562-72, 2015-Apr.

1873-3336

10.1016/j.jhazmat.2014.12.021

http://www.ncbi.nlm.nih.gov/pubmed/25636059

http://repositorio.unicamp.br/jspui/handle/REPOSIP/202083

25636059

Idioma(s)

eng

Relação

Journal Of Hazardous Materials

J. Hazard. Mater.

Direitos

fechado

Copyright © 2014 Elsevier B.V. All rights reserved.

Fonte

PubMed

Palavras-Chave #Herbicides #Natural Organic Matter #Paraquat #Polymeric Nanoparticles #Toxicity
Tipo

Artigo de periódico