Antiproliferative Activity Of Synthetic Fatty Acid Amides From Renewable Resources.
| Contribuinte(s) |
UNIVERSIDADE DE ESTADUAL DE CAMPINAS |
|---|---|
| Data(s) |
01/01/2015
27/11/2015
27/11/2015
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| Resumo |
In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer. 23 340-7 |
| Identificador |
Bioorganic & Medicinal Chemistry. v. 23, n. 2, p. 340-7, 2015-Jan. 1464-3391 10.1016/j.bmc.2014.11.019 http://www.ncbi.nlm.nih.gov/pubmed/25510639 http://repositorio.unicamp.br/jspui/handle/REPOSIP/202002 25510639 |
| Idioma(s) |
eng |
| Relação |
Bioorganic & Medicinal Chemistry Bioorg. Med. Chem. |
| Direitos |
fechado Copyright © 2014 Elsevier Ltd. All rights reserved. |
| Fonte |
PubMed |
| Palavras-Chave | #Glioma #Multidrug Resistance #Ovarian Cancer #Ricinoleic Acid |
| Tipo |
Artigo de periódico |
