Indole-3-carbinol Attenuates The Deleterious Gestational Effects Of Bisphenol A Exposure On The Prostate Gland Of Male F1 Rats.


Autoria(s): Brandt, Joyce Zalotti; Silveira, Lívia Teresa R; Grassi, Tony Fernando; Anselmo-Franci, Janete A; Fávaro, Wagner José; Felisbino, Sérgio Luis; Barbisan, Luis Fernando; Scarano, Wellerson Rodrigo
Contribuinte(s)

UNIVERSIDADE DE ESTADUAL DE CAMPINAS

Data(s)

01/01/2014

27/11/2015

27/11/2015

Resumo

Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.

43

56-66

Identificador

Reproductive Toxicology (elmsford, N.y.). v. 43, p. 56-66, 2014-Jan.

1873-1708

10.1016/j.reprotox.2013.11.001

http://www.ncbi.nlm.nih.gov/pubmed/24257414

http://repositorio.unicamp.br/jspui/handle/REPOSIP/201738

24257414

Idioma(s)

eng

Relação

Reproductive Toxicology (elmsford, N.y.)

Reprod. Toxicol.

Direitos

fechado

Copyright © 2013 Elsevier Inc. All rights reserved.

Fonte

PubMed

Palavras-Chave #Animals #Apoptosis #Benzhydryl Compounds #Cell Proliferation #Endocrine Disruptors #Epithelial Cells #Estrogen Receptor Alpha #Female #Indoles #Male #Maternal-fetal Exchange #Phenols #Pregnancy #Prenatal Exposure Delayed Effects #Prostate #Protective Agents #Rats #Rats, Sprague-dawley #Receptors, Androgen #Receptors, Thrombin #Bisphenol A #Chemoprevention #Indole-3-carbinol #Inflammation #Prostate #Reproductive Toxicology
Tipo

Artigo de periódico