Indole-3-carbinol Attenuates The Deleterious Gestational Effects Of Bisphenol A Exposure On The Prostate Gland Of Male F1 Rats.
Contribuinte(s) |
UNIVERSIDADE DE ESTADUAL DE CAMPINAS |
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Data(s) |
01/01/2014
27/11/2015
27/11/2015
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Resumo |
Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. 43 56-66 |
Identificador |
Reproductive Toxicology (elmsford, N.y.). v. 43, p. 56-66, 2014-Jan. 1873-1708 10.1016/j.reprotox.2013.11.001 http://www.ncbi.nlm.nih.gov/pubmed/24257414 http://repositorio.unicamp.br/jspui/handle/REPOSIP/201738 24257414 |
Idioma(s) |
eng |
Relação |
Reproductive Toxicology (elmsford, N.y.) Reprod. Toxicol. |
Direitos |
fechado Copyright © 2013 Elsevier Inc. All rights reserved. |
Fonte |
PubMed |
Palavras-Chave | #Animals #Apoptosis #Benzhydryl Compounds #Cell Proliferation #Endocrine Disruptors #Epithelial Cells #Estrogen Receptor Alpha #Female #Indoles #Male #Maternal-fetal Exchange #Phenols #Pregnancy #Prenatal Exposure Delayed Effects #Prostate #Protective Agents #Rats #Rats, Sprague-dawley #Receptors, Androgen #Receptors, Thrombin #Bisphenol A #Chemoprevention #Indole-3-carbinol #Inflammation #Prostate #Reproductive Toxicology |
Tipo |
Artigo de periódico |