Potential strategies for the eradication of multi-drug resistant Gram-negative bacterial infections
Data(s) |
01/07/2016
31/12/1969
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Formato |
application/pdf |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/embargoedAccess |
Fonte |
Huwaitat , R , McCloskey , A P , Gilmore , B F & Laverty , G 2016 , ' Potential strategies for the eradication of multi-drug resistant Gram-negative bacterial infections ' Future microbiology , vol 11 , no. 7 , pp. 955-972 . DOI: 10.2217/fmb-2016-0035 |
Tipo |
article |
Resumo |
Antimicrobial resistance is one of the leading threats to society. The increasing burden of multidrug-resistant Gram-negative infection is particularly concerning as such bacteria are demonstrating resistance to nearly all currently licensed therapies. Various strategies have been hypothesized to treat multidrug-resistant Gram-negative infections including: targeting the Gram-negative outer membrane; neutralization of lipopolysaccharide; inhibition of bacterial efflux pumps and prevention of protein folding. Silver and silver nanoparticles, fusogenic liposomes and nanotubes are potential strategies for extending the activity of licensed, Gram-positive selective, antibiotics to Gram-negatives. This may serve as a strategy to fill the current void in pharmaceutical development in the short term. This review outlines the most promising strategies that could be implemented to solve the threat of multidrug-resistant Gram-negative infections |