Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors

Autoria(s): Ness, Kerry Anne; Eddie, Sharon L; Burton, Stephanie; Harrison, Timothy; Mullan, Paul; Williams, Rich
Data(s)

15/01/2016
Resumo

<p>This letter describes the design, development and SAR exploration of a novel series of small legumain inhibitors. The SAR of a new small molecule legumain inhibitor chemotype was explored and found to have improved physiochemical properties compared to previously developed inhibitors within our group. However, further development of this series was found to be limited as the SAR was observed to be relatively flat.</p>
Identificador

http://pure.qub.ac.uk/portal/en/publications/flat-sar-of-p3methylsulphonamide-based-small-molecule-legumain-inhibitors(fa256c29-e39e-4216-b205-6b41c51ca225).html

http://dx.doi.org/10.1016/j.bmcl.2015.11.101
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Ness , K A , Eddie , S L , Burton , S , Harrison , T , Mullan , P & Williams , R 2016 , ' Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors ' Bioorganic and Medicinal Chemistry Letters , vol 26 , no. 2 , pp. 413-6 . DOI: 10.1016/j.bmcl.2015.11.101
Tipo

article
Acesso ao item digital