Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation

Autoria(s): Hardikar, Anandwardhan A.; Satoor, Sarang N.; Karandikar, Mahesh S.; Joglekar, Mugdha V.; Puranik, Amrutesh S.; Wong, Wilson; Kumar, Sandeep; Limaye, Amita; Bhat, Dattatray S.; Januszewski, Andrzej S.; Umrani, Malati R.; Ranjan, Amaresh K.; Apte, Kishori; Yajnik, Pranav; Bhonde, Ramesh R.; Galande, Sanjeev; Keech, Anthony C.; Jenkins, Alicia J.; Yajnik, Chittaranjan S.
Data(s)

04/08/2015
Resumo

<p>People in developing countries have faced multigenerational undernutrition and are currently undergoing major lifestyle changes, contributing to an epidemic of metabolic diseases, though the underlying mechanisms remain unclear. Using a Wistar rat model of undernutrition over 50 generations, we show that Undernourished rats exhibit low birth-weight, high visceral adiposity (DXA/MRI), and insulin resistance (hyperinsulinemic-euglycemic clamps), compared to age-/gender-matched control rats. Undernourished rats also have higher circulating insulin, homocysteine, endotoxin and leptin levels, lower adiponectin, vitamin B12 and folate levels, and an 8-fold increased susceptibility to Streptozotocin-induced diabetes compared to control rats. Importantly, these metabolic abnormalities are not reversed after two generations of unrestricted access to commercial chow (nutrient recuperation). Altered epigenetic signatures in insulin-2 gene promoter region of Undernourished rats are not reversed by nutrient recuperation, and may contribute to the persistent detrimental metabolic profiles in similar multigenerational undernourished human populations.</p>
Identificador

http://pure.qub.ac.uk/portal/en/publications/multigenerational-undernutrition-increases-susceptibility-to-obesity-and-diabetes-that-is-not-reversed-after-dietary-recuperation(197c2be0-d98a-4ff1-ac56-83e8c6ba958a).html

http://dx.doi.org/10.1016/j.cmet.2015.06.008

http://www.scopus.com/inward/record.url?scp=84938741329&partnerID=8YFLogxK
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Hardikar , A A , Satoor , S N , Karandikar , M S , Joglekar , M V , Puranik , A S , Wong , W , Kumar , S , Limaye , A , Bhat , D S , Januszewski , A S , Umrani , M R , Ranjan , A K , Apte , K , Yajnik , P , Bhonde , R R , Galande , S , Keech , A C , Jenkins , A J & Yajnik , C S 2015 , ' Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation ' Cell metabolism , vol 22 , no. 2 , pp. 312-319 . DOI: 10.1016/j.cmet.2015.06.008
Tipo

article
Acesso ao item digital