HOXB13, RFX6 and prostate cancer risk
| Data(s) |
01/02/2014
|
|---|---|
| Resumo |
<p>A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.</p> |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Mills , I G 2014 , ' HOXB13, RFX6 and prostate cancer risk ' Nature Genetics , vol 46 , no. 2 , pp. 94-5 . DOI: 10.1038/ng.2881 |
| Palavras-Chave | #Chromatin #Chromosomes, Human, Pair 6 #DNA-Binding Proteins #Gene Expression Regulation, Neoplastic #Genetic Predisposition to Disease #Homeodomain Proteins #Humans #Male #Prostatic Neoplasms #Transcription Factors |
| Tipo |
article |
