Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era


Autoria(s): Socie, G; Lawler, M; Gluckman, E; McCann, S R; Brison, O; Lawler, Mark
Data(s)

01/08/1995

Resumo

<p>Donor hematopoiesis or donor chimerism in the host following allogeneic bone marrow transplantation (BMT) has appeared crucial to the engraftment process. However, as molecular techniques exploiting neutral variation in human genetic material have been used in the study of chimerism, the detection of residual host cells or mixed hemopoietic chimerism has indicated that donor chimerism is not obligatory following BMT. This review focuses on the detection and significance of mixed chimerism (MC) in patients transplanted for both malignant and non-malignant hemopoietic disease and attempts to tease out the contribution of MC to engraftment, leukemia relapse, graft rejection and long-term disease-free survival.</p>

Identificador

http://pure.qub.ac.uk/portal/en/publications/studies-on-hemopoietic-chimerism-following-allogeneic-bone-marrow-transplantation-in-the-molecular-biology-era(5f54aeee-66cb-439f-bfd6-0ea03397218d).html

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Socie , G , Lawler , M , Gluckman , E , McCann , S R , Brison , O & Lawler , M 1995 , ' Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology era ' Leukemia research , vol 19 , no. 8 , pp. 497-504 .

Palavras-Chave #Anemia, Aplastic #Bone Marrow Transplantation #Chimera #Graft vs Host Disease #Hematopoiesis #Humans #Leukemia #Neoplasm, Residual #Polymerase Chain Reaction #Polymorphism, Genetic #beta-Thalassemia
Tipo

article