Genomics and the impact of new technologies on the management of colorectal cancer
Data(s) |
01/10/2006
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Resumo |
High-throughput genomic technologies have the potential to have a major impact on preclinical and clinical drug development and the selection and stratification of patients in clinical trials. These technologies, which are at varying stages of commercialization, include array-based comparative genomic hybridization, single-nucleotide polymorphism arrays, and (the most mature example) expression-based arrays. One of the rate-limiting steps in the routine clinical application of expression array-based technology is the need for suitable clinical samples. One of the major challenges moving forward, therefore, relates to the ability to use formalin-fixed, paraffin-embedded--derived tissue in expression profiling-based approaches. |
Identificador |
http://dx.doi.org/10.1634/theoncologist.11-9-988 http://www.scopus.com/inward/record.url?scp=33749864510&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Harkin , D P 2006 , ' Genomics and the impact of new technologies on the management of colorectal cancer ' The Oncologist , vol 11 , no. 9 , pp. 988-991 . DOI: 10.1634/theoncologist.11-9-988 |
Palavras-Chave | #Array-based comparative genomic hybridization #Formalin-fixed paraffin-embedded #Genomics #Microarrays #RNA later #Single-nucleotide polymorphism arrays #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology |
Tipo |
article |