Hui and Walter's latent-class model extended to estimate diagnostic test properties from surveillance data: a latent model for latent data


Autoria(s): Bermingham, Mairead L.; Handel, Ian G.; Glass, Elizabeth J.; Woolliams, John A.; Bronsvoort, B. Mark de Clare; McBride, Stewart H.; Skuce, Robin A.; Allen, Adrian R.; McDowell, Stanley W. J.; Bishop, Stephen C.
Data(s)

07/07/2015

Resumo

<p>Diagnostic test sensitivity and specificity are probabilistic estimates with far reaching implications for disease control, management and genetic studies. In the absence of 'gold standard' tests, traditional Bayesian latent class models may be used to assess diagnostic test accuracies through the comparison of two or more tests performed on the same groups of individuals. The aim of this study was to extend such models to estimate diagnostic test parameters and true cohort-specific prevalence, using disease surveillance data. The traditional Hui-Walter latent class methodology was extended to allow for features seen in such data, including (i) unrecorded data (i.e. data for a second test available only on a subset of the sampled population) and (ii) cohort-specific sensitivities and specificities. The model was applied with and without the modelling of conditional dependence between tests. The utility of the extended model was demonstrated through application to bovine tuberculosis surveillance data from Northern and the Republic of Ireland. Simulation coupled with re-sampling techniques, demonstrated that the extended model has good predictive power to estimate the diagnostic parameters and true herd-level prevalence from surveillance data. Our methodology can aid in the interpretation of disease surveillance data, and the results can potentially refine disease control strategies.</p>

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/hui-and-walters-latentclass-model-extended-to-estimate-diagnostic-test-properties-from-surveillance-data-a-latent-model-for-latent-data(5da99385-2733-4342-bff5-f88c0da9e263).html

http://dx.doi.org/10.1038/srep11861

http://pure.qub.ac.uk/ws/files/16208401/Hui.pdf

Idioma(s)

eng

Direitos

info:eu-repo/semantics/openAccess

Fonte

Bermingham , M L , Handel , I G , Glass , E J , Woolliams , J A , Bronsvoort , B M D C , McBride , S H , Skuce , R A , Allen , A R , McDowell , S W J & Bishop , S C 2015 , ' Hui and Walter's latent-class model extended to estimate diagnostic test properties from surveillance data: a latent model for latent data ' Scientific Reports , vol 5 , 11861 . DOI: 10.1038/srep11861

Palavras-Chave #GOLD STANDARD #TEST ACCURACY #BOVINE TUBERCULOSIS #DISEASE PREVALENCE #ERROR RATES #SENSITIVITY #SPECIFICITY #PARATUBERCULOSIS #ANTIBODIES #SAMPLES
Tipo

article