Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)


Autoria(s): Heaney, Liam G.; Djukanović, Ratko; Woodcock, Ashley; Walker, Samantha; Matthews, John G.; Pavord, Ian D.; Bradding, Peter; Niven, Robert; Brightling, Chris E.; Chaudhuri, Rekha; Arron, Joseph R.; Choy, David F.; Cowan, Douglas; Mansur, Adel; Menzies-Gow, Andrew; Adcock, Ian; Chung, Kian F.; Corrigan, Chris; Coyle, Peter; Harrison, Timothy; Johnston, Sebastian; Howarth, Peter; Lordan, James; Sabroe, Ian; Bigler, Jeannette; Smith, Dirk; Cattley, Matthew; May, Richard; Pierre, Lisa; Stevenson, Chris; Crater, Glenn; Keane, Frank; Costello, R.W.; Hudson, Val; Supple, David; Hardman, Tim; RASP-UK Consortium
Data(s)

23/07/2015

Resumo

The UK Refractory Asthma Stratification Programme(RASP-UK) will explore novel biomarker stratificationstrategies in severe asthma to improve clinicalmanagement and accelerate development of newtherapies. Prior asthma mechanistic studies have notstratified on inflammatory phenotype and theunderstanding of pathophysiological mechanisms inasthma without Type 2 cytokine inflammation is limited.RASP-UK will objectively assess adherence tocorticosteroids (CS) and examine a novel compositebiomarker strategy to optimise CS dose; this will alsoaddress what proportion of patients with severe asthmahave persistent symptoms without eosinophilic airwaysinflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/research-in-progress-medical-research-council-united-kingdom-refractory-asthma-stratification-programme-raspuk(1bde6555-75d1-4aed-89f5-7276892be0e0).html

http://dx.doi.org/10.1136/thoraxjnl-2015-207326

http://pure.qub.ac.uk/ws/files/16293568/Research_in_progress.pdf

Idioma(s)

eng

Direitos

info:eu-repo/semantics/openAccess

Fonte

Heaney , L G , Djukanović , R , Woodcock , A , Walker , S , Matthews , J G , Pavord , I D , Bradding , P , Niven , R , Brightling , C E , Chaudhuri , R , Arron , J R , Choy , D F , Cowan , D , Mansur , A , Menzies-Gow , A , Adcock , I , Chung , K F , Corrigan , C , Coyle , P , Harrison , T , Johnston , S , Howarth , P , Lordan , J , Sabroe , I , Bigler , J , Smith , D , Cattley , M , May , R , Pierre , L , Stevenson , C , Crater , G , Keane , F , Costello , R W , Hudson , V , Supple , D , Hardman , T & RASP-UK Consortium 2015 , ' Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK) ' Thorax . DOI: 10.1136/thoraxjnl-2015-207326

Tipo

article