The use of water soluble mucoadhesive gels for the intravesical delivery of epirubicin to the bladder for the treatment of non-muscle invasive bladder cancer
Data(s) |
01/10/2015
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Resumo |
Objectives: To develop an epirubicin-loaded, water-soluble mucoadhesive gels that have the correct rheological properties to facilitate their delivery into the bladder via a catheter, while allowing for their spread across the bladder wall with limited expansion of the bladder and increasing the retention of epirubicin in the bladder and flushing with urine.<br/><br/>Methods: Epirubicin-loaded hydroxyl ethyl cellulose (HEC) and hydroxy propyl methyl cellulose (HPMC) gels were manufactured and tested for their rheological properties. Their ability to be pushed through a catheter was also assessed as was their in-vitro drug release, spreading in a bladder and retention of epirubicin after flushing with simulated urine.<br/><br/>Key findings: Epirubicin drug release was viscosity-dependent. The 1 and 1.5% HEC gels and the 1, 1.5 and 2% HPMC gels had the correct viscosity to be administered through a model catheter and spread evenly across the bladder wall under the pressure of the detrusor muscle. The epirubicin-loaded gels had an increased retention time in the bladder when compared with a standard intravesical solution of epirubicin, even after successive flushes with simulated urine.<br/><br/>Conclusion: The increased retention of epirubicin in the bladder by the HEC and HPMC gels warrant further investigation, using an in-vivo model, to assess their potential for use as treatment for non-muscle-invasive bladder cancer. |
Identificador |
http://dx.doi.org/10.1111/jphp.12441 http://pure.qub.ac.uk/ws/files/16723782/water.pdf http://pure.qub.ac.uk/ws/files/16723783/water_figure_1.pdf http://pure.qub.ac.uk/ws/files/16723784/water_figure_2.pdf |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Chatta , D , Cottrell , L , Burnett , B , Laverty , G & McConville , C 2015 , ' The use of water soluble mucoadhesive gels for the intravesical delivery of epirubicin to the bladder for the treatment of non-muscle invasive bladder cancer ' Journal of Pharmacy and Pharmacology , vol 67 , no. 10 , pp. 1355-1362 . DOI: 10.1111/jphp.12441 |
Tipo |
article |
Formato |
application/pdf application/pdf application/pdf application/pdf application/pdf |