STC-1 Cells
| Contribuinte(s) |
Verhoeckx, Kitty Cotter, Paul López-Expósito, Iván Kleiveland, Charlotte Lea, Tor Mackie, Alan Requena, Teresa Swiatecka, Dominika Wichers, Harry |
|---|---|
| Data(s) |
2015
|
| Resumo |
Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds. |
| Identificador |
http://pure.qub.ac.uk/portal/en/publications/stc1-cells(a1176863-4037-4557-928d-77812776c93c).html |
| Idioma(s) |
eng |
| Publicador |
Springer |
| Direitos |
info:eu-repo/semantics/closedAccess |
| Fonte |
McCarthy , T , Green , B D , Calderwood , D , Gillespie , A , Cryan , J F & Giblin , L 2015 , STC-1 Cells . in K Verhoeckx , P Cotter , I López-Expósito , C Kleiveland , T Lea , A Mackie , T Requena , D Swiatecka & H Wichers (eds) , The Impact of Food Bioactives on Health: in vitro and ex vivo models . vol. Part IV , Springer , pp. 211-220 . DOI: 10.1007/978-3-319-16104-4_19 |
| Tipo |
contributionToPeriodical |
| Formato |
application/pdf |
