Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population

Autoria(s): Douglas, Adam P.; Vance, Dwaine R.; Kenny, Elaine M.; Morris, Derek W.; Maxwell, Alexander P.; McKnight, Amy Jayne
Data(s)

09/12/2014
Resumo

<p>Kidneys are highly aerobic organs that are critically dependent on the normal functioning of mitochondria. Genetic variations disrupting mitochondrial function are associated with multifactorial disorders including kidney disease. This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64 individuals, using next-generation sequencing, to evaluate the association of genetic variants with IgA nephropathy and end-stage renal disease (ESRD, n = 100).</p>
Formato

application/pdf
Identificador

http://pure.qub.ac.uk/portal/en/publications/nextgeneration-sequencing-of-the-mitochondrial-genome-and-association-with-iga-nephropathy-in-a-renal-transplant-population(5600a0c0-a8a5-4c40-a0fc-c1195266f740).html

http://dx.doi.org/10.1038/srep07379

http://pure.qub.ac.uk/ws/files/13445841/Next_generation_sequencing_of_the_mitochondrial_genome_and_association_with_IgA_nephropathy_in_a_renal_transplant_population.pdf
Idioma(s)

eng
Direitos

info:eu-repo/semantics/openAccess
Fonte

Douglas , A P , Vance , D R , Kenny , E M , Morris , D W , Maxwell , A P & McKnight , A J 2014 , ' Next-generation sequencing of the mitochondrial genome and association with IgA nephropathy in a renal transplant population ' Scientific Reports , vol 4 , pp. 7379 . DOI: 10.1038/srep07379
Tipo

article
Acesso ao item digital