Synthesis and release kinetics of polymerisable ester drug conjugates towards pH-responsive infection-resistant urinary biomaterials
| Data(s) |
15/05/2013
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| Resumo |
<p>Herein we report the synthesis, characterisation and hydrolytic release kinetics of a suite of novel, polymerisable ester quinolone conjugates with varying alkenyl chain lengths. Hydrolysis was shown to proceed up to 17-fold faster upon elevation of pH from neutral to pH 9.29, making these conjugates attractive for the development of 'designer' infection-resistant urinary biomaterials exploiting the increase in urine pH reported at the onset of catheter-associated infection to trigger drug release. (C) 2013 Elsevier Ltd. All rights reserved.</p> |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
McCoy , C P , Irwin , N J , Brady , C , Jones , D S , Andrews , G P & Gorman , S P 2013 , ' Synthesis and release kinetics of polymerisable ester drug conjugates towards pH-responsive infection-resistant urinary biomaterials ' Tetrahedron Letters , vol 54 , no. 20 , pp. 2511-2514 . DOI: 10.1016/j.tetlet.2013.03.020 |
| Palavras-Chave | #Chain length #pH elevation #Ester hydrolysis #Drug-polymer conjugates |
| Tipo |
article |
