Optical coherence tomography for the diagnosis of neovascular age-related macular degeneration: a systematic review


Autoria(s): Castillo, M M; Mowatt, G; Lois, N; Elders, A; Fraser, C; Amoaku, W; Burr, J M; Lotery, A J; Ramsay, C R; Azuara-Blanco, A
Data(s)

01/12/2014

Resumo

The purpose is to study the diagnostic performance of optical coherence tomography (OCT) and alternative diagnostic tests for neovascular age-related macular degeneration (nAMD). Methods employed are as follows:systematic review and meta-analysis; Index test: OCT including time-domain (TD-OCT) and the most recently developed spectral domain (SD-OCT); comparator tests: visual acuity, clinical evaluation (slit lamp), Amsler chart, colour fundus photographs, infra-red reflectance, red-free images/blue reflectance, fundus autofluorescence imaging (FAF), indocyanine green angiography (ICGA), preferential hyperacuity perimetry (PHP), and microperimetry; reference standard: fundus fluorescein angiography. Databases searched included MEDLINE, MEDLINE In Process, EMBASE, Biosis, SCI, the Cochrane Library, DARE, MEDION, and HTA database. Last literature searches: March 2013. Risk of bias assessed using QUADAS-2. Meta-analysis models were fitted using hierarchical summary receiver operating characteristic (HSROC) curves. Twenty-two studies (2 abstracts and 20 articles) enrolling 2124 participants were identified, reporting TD-OCT (12 studies), SD-OCT (1 study), ICGA (8 studies), PHP (3 studies), Amsler grid, colour fundus photography and FAF (1 study each). Most studies were considered to have a high risk of bias in the patient selection (55%, 11/20), and flow and timing (40%, 8/20) domains. In a meta-analysis of TD-OCT studies, sensitivity and specificity (95% CI) were 88% (46–98%) and 78% (64–88%), respectively. There was insufficient information to undertake meta-analysis for other tests. TD-OCT is a sensitive test for detecting nAMD, although specificity was only moderate. Data on SD-OCT are sparse. Diagnosis of nAMD should not rely solely on OCT.

Identificador

http://pure.qub.ac.uk/portal/en/publications/optical-coherence-tomography-for-the-diagnosis-of-neovascular-agerelated-macular-degeneration-a-systematic-review(80cc3533-22b7-43b0-85a1-64e826711781).html

http://dx.doi.org/10.1038/eye.2014.214

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Castillo , M M , Mowatt , G , Lois , N , Elders , A , Fraser , C , Amoaku , W , Burr , J M , Lotery , A J , Ramsay , C R & Azuara-Blanco , A 2014 , ' Optical coherence tomography for the diagnosis of neovascular age-related macular degeneration: a systematic review ' Eye , vol 28 . DOI: 10.1038/eye.2014.214

Tipo

article