Large-scale association analysis identifies new risk loci for coronary artery disease
| Data(s) |
01/01/2013
|
|---|---|
| Resumo |
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Deloukas , P , Kanoni , S , Willenborg , C , Farrall , M , Assimes , T L , Thompson , J R , Ingelsson , E , Saleheen , D , Erdmann , J , Goldstein , B A , Stirrups , K , König , I R , Cazier , J-B , Johansson , A , Hall , A S , Lee , J-Y , Willer , C J , Chambers , J C , Esko , T , Folkersen , L , Goel , A , Grundberg , E , Havulinna , A S , Ho , W K , Hopewell , J C , Eriksson , N , Kleber , M E , Kristiansson , K , Lundmark , P , Lyytikäinen , L-P , Rafelt , S , Shungin , D , Strawbridge , R J , Thorleifsson , G , Tikkanen , E , Van Zuydam , N , Voight , B F , Waite , L L , Zhang , W , Ziegler , A , Absher , D , Altshuler , D , Balmforth , A J , Barroso , I , Braund , P S , Burgdorf , C , Claudi-Boehm , S , Cox , D , Dimitriou , M , Do , R , Doney , A S F , El Mokhtari , N , Eriksson , P , Fischer , K , Fontanillas , P , Franco-Cereceda , A , Gigante , B , Groop , L , Gustafsson , S , Hager , J , Hallmans , G , Han , B-G , Hunt , S E , Kang , H M , Illig , T , Kessler , T , Knowles , J W , Kolovou , G , Kuusisto , J , Langenberg , C , Langford , C , Leander , K , Lokki , M-L , Lundmark , A , McCarthy , M I , Meisinger , C , Melander , O , Mihailov , E , Maouche , S , Morris , A D , Müller-Nurasyid , M , Nikus , K , Peden , J F , Rayner , N W , Rasheed , A , Rosinger , S , Rubin , D , Rumpf , M P , Schäfer , A , Sivananthan , M , Song , C , Stewart , A F R , Tan , S-T , Thorgeirsson , G , van der Schoot , C E , Wagner , P J , Wells , G A , Wild , P S , Yang , T-P , Amouyel , P , Arveiler , D , Basart , H , Boehnke , M , Boerwinkle , E , Brambilla , P , Cambien , F , Cupples , A L , de Faire , U , Dehghan , A , Diemert , P , Epstein , S E , Evans , A , Ferrario , M M , Ferrières , J , Gauguier , D , Go , A S , Goodall , A H , Gudnason , V , Hazen , S L , Holm , H , Iribarren , C , Jang , Y , Kähönen , M , Kee , F , Kim , H-S , Klopp , N , Koenig , W , Kratzer , W , Kuulasmaa , K , Laakso , M , Laaksonen , R , Lee , J-Y , Lind , L , Ouwehand , W H , Parish , S , Park , J E , Pedersen , N L , Peters , A , Quertermous , T , Rader , D J , Salomaa , V , Schadt , E , Shah , S H , Sinisalo , J , Stark , K , Stefansson , K , Trégouët , D-A , Virtamo , J , Wallentin , L , Wareham , N , Zimmermann , M E , Nieminen , M S , Hengstenberg , C , Sandhu , M S , Pastinen , T , Syvänen , A-C , Hovingh , G K , Dedoussis , G , Franks , P W , Lehtimäki , T , Metspalu , A , Zalloua , P A , Siegbahn , A , Schreiber , S , Ripatti , S , Blankenberg , S S , Perola , M , Clarke , R , Boehm , B O , O'Donnell , C , Reilly , M P , März , W , Collins , R , Kathiresan , S , Hamsten , A , Kooner , J S , Thorsteinsdottir , U , Danesh , J , Palmer , C N A , Roberts , R , Watkins , H , Schunkert , H , Samani , N J & CARDIoGRAMplusC4D Consortium 2013 , ' Large-scale association analysis identifies new risk loci for coronary artery disease ' Nature genetics , vol 45 , no. 1 , pp. 25-33 . DOI: 10.1038/ng.2480 |
| Palavras-Chave | #Adult #Aged #Asian Continental Ancestry Group #Cell Line #Coronary Artery Disease #European Continental Ancestry Group #Female #Gene Regulatory Networks #Genetic Predisposition to Disease #Genome-Wide Association Study #Humans #Male #Middle Aged #Polymorphism, Single Nucleotide #Quantitative Trait Loci #Risk Factors |
| Tipo |
article |
