The role of adiposity in cardiometabolic traits:a Mendelian randomization analysis

Autoria(s): Fall, Tove; Hägg, Sara; Mägi, Reedik; Ploner, Alexander; Fischer, Krista; Horikoshi, Momoko; Sarin, Antti-Pekka; Thorleifsson, Gudmar; Ladenvall, Claes; Kals, Mart; Kuningas, Maris; Draisma, Harmen H M; Ried, Janina S; van Zuydam, Natalie R; Huikari, Ville; Mangino, Massimo; Sonestedt, Emily; Benyamin, Beben; Nelson, Christopher P; Rivera, Natalia V; Kristiansson, Kati; Shen, Huei-Yi; Havulinna, Aki S; Dehghan, Abbas; Donnelly, Louise A; Kaakinen, Marika; Nuotio, Marja-Liisa; Robertson, Neil; de Bruijn, Renée F A G; Ikram, M Arfan; Amin, Najaf; Balmforth, Anthony J; Braund, Peter S; Doney, Alexander S F; Döring, Angela; Elliott, Paul; Esko, Tõnu; Franco, Oscar H; Gretarsdottir, Solveig; Hartikainen, Anna-Liisa; Heikkilä, Kauko; Herzig, Karl-Heinz; Holm, Hilma; Hottenga, Jouke Jan; Hyppönen, Elina; Illig, Thomas; Isaacs, Aaron; Isomaa, Bo; Karssen, Lennart C; Kettunen, Johannes; Koenig, Wolfgang; Kuulasmaa, Kari; Laatikainen, Tiina; Laitinen, Jaana; Lindgren, Cecilia; Lyssenko, Valeriya; Läärä, Esa; Rayner, Nigel W; Männistö, Satu; Pouta, Anneli; Rathmann, Wolfgang; Rivadeneira, Fernando; Ruokonen, Aimo; Savolainen, Markku J; Sijbrands, Eric J G; Small, Kerrin S; Smit, Jan H; Steinthorsdottir, Valgerdur; Syvänen, Ann-Christine; Taanila, Anja; Tobin, Martin D; Uitterlinden, Andre G; Willems, Sara M; Willemsen, Gonneke; Witteman, Jacqueline; Perola, Markus; Evans, Alun; Ferrières, Jean; Virtamo, Jarmo; Kee, Frank; Tregouet, David-Alexandre; Arveiler, Dominique; Amouyel, Philippe; Ferrario, Marco M; Brambilla, Paolo; Hall, Alistair S; Heath, Andrew C; Madden, Pamela A F; Martin, Nicholas G; Montgomery, Grant W; Whitfield, John B; Jula, Antti; Knekt, Paul; Oostra, Ben; van Duijn, Cornelia M; Penninx, Brenda W J H; Davey Smith, George; Kaprio, Jaakko; Samani, Nilesh J; Gieger, Christian; Peters, Annette; Wichmann, H Erich; Boomsma, Dorret I; de Geus, Eco J C; Tuomi, TiinaMaija; Power, Chris; Hammond, Christopher J; Spector, Tim D; Lind, Lars; Orho-Melander, Marju; Palmer, Colin Neil Alexander; Morris, Andrew D; Groop, Leif; Järvelin, Marjo-Riitta; Salomaa, Veikko; Vartiainen, Erkki; Hofman, Albert; Ripatti, Samuli; Metspalu, Andres; Thorsteinsdottir, Unnur; Stefansson, Kari; Pedersen, Nancy L; McCarthy, Mark I; Ingelsson, Erik; Prokopenko, Inga; European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium
Data(s)

2013
Resumo

The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach.
Identificador

http://pure.qub.ac.uk/portal/en/publications/the-role-of-adiposity-in-cardiometabolic-traits(c38db31e-313b-493e-8ad8-9103bdaf3627).html

http://dx.doi.org/10.1371/journal.pmed.1001474
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Fall , T , Hägg , S , Mägi , R , Ploner , A , Fischer , K , Horikoshi , M , Sarin , A-P , Thorleifsson , G , Ladenvall , C , Kals , M , Kuningas , M , Draisma , H H M , Ried , J S , van Zuydam , N R , Huikari , V , Mangino , M , Sonestedt , E , Benyamin , B , Nelson , C P , Rivera , N V , Kristiansson , K , Shen , H-Y , Havulinna , A S , Dehghan , A , Donnelly , L A , Kaakinen , M , Nuotio , M-L , Robertson , N , de Bruijn , R F A G , Ikram , M A , Amin , N , Balmforth , A J , Braund , P S , Doney , A S F , Döring , A , Elliott , P , Esko , T , Franco , O H , Gretarsdottir , S , Hartikainen , A-L , Heikkilä , K , Herzig , K-H , Holm , H , Hottenga , J J , Hyppönen , E , Illig , T , Isaacs , A , Isomaa , B , Karssen , L C , Kettunen , J , Koenig , W , Kuulasmaa , K , Laatikainen , T , Laitinen , J , Lindgren , C , Lyssenko , V , Läärä , E , Rayner , N W , Männistö , S , Pouta , A , Rathmann , W , Rivadeneira , F , Ruokonen , A , Savolainen , M J , Sijbrands , E J G , Small , K S , Smit , J H , Steinthorsdottir , V , Syvänen , A-C , Taanila , A , Tobin , M D , Uitterlinden , A G , Willems , S M , Willemsen , G , Witteman , J , Perola , M , Evans , A , Ferrières , J , Virtamo , J , Kee , F , Tregouet , D-A , Arveiler , D , Amouyel , P , Ferrario , M M , Brambilla , P , Hall , A S , Heath , A C , Madden , P A F , Martin , N G , Montgomery , G W , Whitfield , J B , Jula , A , Knekt , P , Oostra , B , van Duijn , C M , Penninx , B W J H , Davey Smith , G , Kaprio , J , Samani , N J , Gieger , C , Peters , A , Wichmann , H E , Boomsma , D I , de Geus , E J C , Tuomi , T , Power , C , Hammond , C J , Spector , T D , Lind , L , Orho-Melander , M , Palmer , C N A , Morris , A D , Groop , L , Järvelin , M-R , Salomaa , V , Vartiainen , E , Hofman , A , Ripatti , S , Metspalu , A , Thorsteinsdottir , U , Stefansson , K , Pedersen , N L , McCarthy , M I , Ingelsson , E , Prokopenko , I & European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium 2013 , ' The role of adiposity in cardiometabolic traits : a Mendelian randomization analysis ' PLoS Medicine , vol 10 , no. 6 , pp. e1001474 . DOI: 10.1371/journal.pmed.1001474
Palavras-Chave #Adiposity #Body Mass Index #Cardiovascular Diseases #Case-Control Studies #Confounding Factors (Epidemiology) #Genetic Association Studies #Humans #Mendelian Randomization Analysis #Meta-Analysis as Topic #Polymorphism, Single Nucleotide #Proteins #Quantitative Trait, Heritable
Tipo

article
Acesso ao item digital