Age-Associated Changes of Brain Copper, Iron, and Zinc in Alzheimer's Disease and Dementia with Lewy Bodies


Autoria(s): Graham, Stewart F; Nasaruddin, Muhammad Bin; Carey, Manus; Holscher, Christian; McGuinness, Bernadette; Kehoe, Patrick G; Love, Seth; Passmore, Peter; Elliott, Christopher T; Meharg, Andrew A; Green, Brian D
Data(s)

13/10/2014

Resumo

Disease-, age-, and gender-associated changes in brain copper, iron, and zinc were assessed in postmortem neocortical tissue (Brodmann area 7) from patients with moderate Alzheimer's disease (AD) (n = 14), severe AD (n = 28), dementia with Lewy bodies (n = 15), and normal age-matched control subjects (n = 26). Copper was lower (20%; p < 0.001) and iron higher (10–16%; p < 0.001) in severe AD compared with controls. Intriguingly significant Group*Age interactions were observed for both copper and iron, suggesting gradual age-associated decline of these metals in healthy non-cognitively impaired individuals. Zinc was unaffected in any disease pathologies and no age-associated changes were apparent. Age-associated changes in brain elements warrant further investigation.

Identificador

http://pure.qub.ac.uk/portal/en/publications/ageassociated-changes-of-brain-copper-iron-and-zinc-in-alzheimers-disease-and-dementia-with-lewy-bodies(0b8e3a90-fca5-477e-a6d7-ac32e032d4f0).html

http://dx.doi.org/10.3233/JAD-140684

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Graham , S F , Nasaruddin , M B , Carey , M , Holscher , C , McGuinness , B , Kehoe , P G , Love , S , Passmore , P , Elliott , C T , Meharg , A A & Green , B D 2014 , ' Age-Associated Changes of Brain Copper, Iron, and Zinc in Alzheimer's Disease and Dementia with Lewy Bodies ' Journal of Alzheimer's disease : JAD , vol 42 , no. 4 , pp. 1407-1413 . DOI: 10.3233/JAD-140684

Tipo

article