Attention-based modulation of tactile stimuli: A comparison between prefrontal lesion patients and healthy age-matched controls
Data(s) |
01/05/2014
|
---|---|
Resumo |
Objectives: To investigate the role of the prefrontal cortex in attention-based modulation of cortical somatosensory processing.<br/><br/>Methods: Six prefrontal stroke patients were compared with eleven neurologically intact older adults during a vibrotactile discrimination task. All subjects attended to stimuli on one digit while ignoring distracter stimuli on a separate digit of the same hand. Subjects were required to report infrequent targets on the attended digit only. Throughout testing electroencephalography was used to measure event-related potentials for both task-relevant and irrelevant stimuli.<br/><br/>Results: Prefrontal patients demonstrated significant changes in cortical somatosensory processing based on attention compared to age-matched controls. This was evident both in early unimodal somatosensory processing (i.e. P100) and in later cortical processing stages (i.e. long-latency positivity). Moreover, there was a tendency towards a tonic loss of inhibition over early somatosensory cortical processing (i.e. P50).<br/><br/>Conclusions: The attention-based modulation noted for neurologically intact older adults was absent in prefrontal lesion patients.<br/><br/>Significance: The present study highlights the important role of prefrontal regions in sustaining inhibition over early sensory cortical processing stages and in modifying somatosensory transmission based on task-relevance. Notably these deficits extend beyond those previously shown to occur as a function of age. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Bolton , D A E & Staines , W R 2014 , ' Attention-based modulation of tactile stimuli: A comparison between prefrontal lesion patients and healthy age-matched controls ' Neuropsychologia , vol 57 , no. 1 , pp. 101-111 . DOI: 10.1016/j.neuropsychologia.2014.03.003 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2800/2802 #Behavioral Neuroscience #/dk/atira/pure/subjectarea/asjc/2800/2805 #Cognitive Neuroscience #/dk/atira/pure/subjectarea/asjc/3200/3205 #Experimental and Cognitive Psychology #/dk/atira/pure/subjectarea/asjc/1200/1201 #Arts and Humanities (miscellaneous) |
Tipo |
article |