Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes


Autoria(s): Syreeni, Anna; El-Osta, Assam; Forsblom, Carol; Sandholm, Niina; Parkkonen, Maikki; Tarnow, Lise; Parving, Hans-Henrik; McKnight, Amy J; Maxwell, Alexander P; Cooper, Mark E; Groop, Per-Henrik; FinnDiane Study Group
Data(s)

01/11/2011

Resumo

Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications often persist and progress despite improved glucose control, possibly as a result of prior episodes of hyperglycemia. Epigenetic modifications mediated by histone methyltransferases are associated with gene-activating events that promote enhanced expression of key proinflammatory molecules implicated in vascular injury. In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular complications in type 1 diabetes.

Identificador

http://pure.qub.ac.uk/portal/en/publications/genetic-examination-of-setd7-and-suv39h1h2-methyltransferases-and-the-risk-of-diabetes-complications-in-patients-with-type-1-diabetes(641605ff-8bae-4bd5-b41e-28817c932ba9).html

http://dx.doi.org/10.2337/db11-0073

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Syreeni , A , El-Osta , A , Forsblom , C , Sandholm , N , Parkkonen , M , Tarnow , L , Parving , H-H , McKnight , A J , Maxwell , A P , Cooper , M E , Groop , P-H & FinnDiane Study Group 2011 , ' Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes ' Diabetes , vol 60 , no. 11 , pp. 3073-80 . DOI: 10.2337/db11-0073

Palavras-Chave #Adult #Cardiovascular Diseases #Cohort Studies #Diabetes Mellitus, Type 1 #Diabetic Angiopathies #Diabetic Nephropathies #Diabetic Retinopathy #Exons #Female #Finland #Gene Frequency #Genetic Association Studies #Histone-Lysine N-Methyltransferase #Humans #Male #Methyltransferases #Microvessels #Middle Aged #Polymorphism, Single Nucleotide #Repressor Proteins
Tipo

article