Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients
Data(s) |
01/05/2014
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Resumo |
Aim: To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function. Methods: PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n = 246) in whom serum was obtained early in the VADT (2.0 ± 0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years. Results: Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p < 0.05). Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p > 0.09). Conclusions: Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1 years. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Jenkins , A J , Fu , D , Azar , M , Stoner , J A , Kaufman , D G , Zhang , S , Klein , R L , Lopes-Virella , M F , Ma , J-X , Lyons , T J & VADT investigators 2014 , ' Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients ' Journal of diabetes and its complications , vol 28 , no. 3 . DOI: 10.1016/j.jdiacomp.2014.01.008 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2724 #Internal Medicine #/dk/atira/pure/subjectarea/asjc/2700/2712 #Endocrinology, Diabetes and Metabolism #/dk/atira/pure/subjectarea/asjc/1300/1310 #Endocrinology |
Tipo |
article |