Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose


Autoria(s): Dvorakova, M.; Nencka, R.; Dejmek, M.; Zbornikova, E.; Brezinova, A.; Pribylova, M.; Pohl, R.; Migaud, M.E.; Vanek, T.
Data(s)

14/09/2013

Resumo

The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1. © 2013 The Royal Society of Chemistry.

Identificador

http://pure.qub.ac.uk/portal/en/publications/synthesis-of-alkylcarbonate-analogs-of-oacetyladpribose(61ddae55-4987-48cd-8b0e-78066b2998c0).html

http://dx.doi.org/10.1039/c3ob41016a

http://www.scopus.com/inward/record.url?eid=2-s2.0-84882329933&partnerID=8YFLogxK

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Dvorakova , M , Nencka , R , Dejmek , M , Zbornikova , E , Brezinova , A , Pribylova , M , Pohl , R , Migaud , M E & Vanek , T 2013 , ' Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose ' Organic and Biomolecular Chemistry , vol 11 , no. 34 , pp. 5702-5713 . DOI: 10.1039/c3ob41016a

Tipo

article