Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
| Data(s) |
01/08/2002
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| Resumo |
Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In the present study, family-based association analysis of 36 simple sequence-length-polymorphism markers and of 17 SNP markers implicated two regions, separated by approximately 7 Mb. The first region, and the focus of this report, is 6p22.3. In this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia. Uncorrected, empirical P values produced by the program TRANSMIT were significant (P |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Straub , R E , Jiang , Y , MacLean , C J , Ma , Y , Webb , B T , Myakishev , M V , Harris-Kerr , C , Wormley , B , Sadek , H , Kadambi , B , Cesare , A J , Gibberman , A , Wang , X , O'Neill , F A , Walsh , D & Kendler , K S 2002 , ' Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia ' The American Journal of Human Genetics , vol 71 , no. 2 , pp. 337-48 . DOI: 10.1086/341750 |
| Palavras-Chave | #Animals #Carrier Proteins #Chromosome Mapping #Chromosomes, Human, Pair 6 #Female #Genetic Markers #Haplotypes #Humans #Male #Mice #Pedigree #Polymorphism, Single Nucleotide #Schizophrenia |
| Tipo |
article |
