Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Autoria(s): Ripke, Stephan; O'Dushlaine, Colm; Chambert, Kimberly; Moran, Jennifer L; Kähler, Anna K; Akterin, Susanne; Bergen, Sarah E; Collins, Ann L; Crowley, James J; Fromer, Menachem; Kim, Yunjung; Lee, Sang Hong; Magnusson, Patrik K E; Sanchez, Nick; Stahl, Eli A; Williams, Stephanie; Wray, Naomi R; Xia, Kai; Bettella, Francesco; Borglum, Anders D; Bulik-Sullivan, Brendan K; Cormican, Paul; Craddock, Nick; de Leeuw, Christiaan; Durmishi, Naser; Gill, Michael; Golimbet, Vera; Hamshere, Marian L; Holmans, Peter; Hougaard, David M; Kendler, Kenneth S; Lin, Kuang; Morris, Derek W; Mors, Ole; Mortensen, Preben B; Neale, Benjamin M; O'Neill, Francis A; Owen, Michael J; Milovancevic, Milica Pejovic; Posthuma, Danielle; Powell, John; Richards, Alexander L; Riley, Brien P; Ruderfer, Douglas; Rujescu, Dan; Sigurdsson, Engilbert; Silagadze, Teimuraz; Smit, August B; Stefansson, Hreinn; Steinberg, Stacy; Suvisaari, Jaana; Tosato, Sarah; Verhage, Matthijs; Walters, James T; Levinson, Douglas F; Gejman, Pablo V; Kendler, Kenneth S; Laurent, Claudine; Mowry, Bryan J; O'Donovan, Michael C; Owen, Michael J; Pulver, Ann E; Riley, Brien P; Schwab, Sibylle G; Wildenauer, Dieter B; Dudbridge, Frank; Holmans, Peter; Shi, Jianxin; Albus, Margot; Alexander, Madeline; Campion, Dominique; Cohen, David; Dikeos, Dimitris; Duan, Jubao; Eichhammer, Peter; Godard, Stephanie; Hansen, Mark; Lerer, F Bernard; Liang, Kung-Yee; Maier, Wolfgang; Mallet, Jacques; Nertney, Deborah A; Nestadt, Gerald; Norton, Nadine; O'Neill, Francis A; Papadimitriou, George N; Ribble, Robert; Sanders, Alan R; Silverman, Jeremy M; Walsh, Dermot; Williams, Nigel M; Wormley, Brandon; Arranz, Maria J; Bakker, Steven; Bender, Stephan; Bramon, Elvira; Collier, David; Crespo-Facorro, Benedicto; Hall, Jeremy; Iyegbe, Conrad; Jablensky, Assen; Kahn, Rene S; Kalaydjieva, Luba; Lawrie, Stephen; Lewis, Cathryn M; Lin, Kuang; Linszen, Don H; Mata, Ignacio; McIntosh, Andrew; Murray, Robin M; Ophoff, Roel A; Powell, John; Rujescu, Dan; Van Os, Jim; Walshe, Muriel; Weisbrod, Matthias; Wiersma, Durk; Donnelly, Peter; Barroso, Ines; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden P; Deloukas, Panos; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; Palmer, Colin N A; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Trembath, Richard C; Viswanathan, Ananth C; Wood, Nicholas W; Spencer, Chris C A; Band, Gavin; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard D; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Donnelly, Peter; Langford, Cordelia; Hunt, Sarah E; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T; Liddle, Jennifer; Potter, Simon C; Ravindrarajah, Radhi; Ricketts, Michelle; Tashakkori-Ghanbaria, Avazeh; Waller, Matthew J; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Barroso, Ines; Deloukas, Panos; Mathew, Christopher G; Blackwell, Jenefer M; Brown, Matthew A; Corvin, Aiden P; McCarthy, Mark I; Spencer, Chris C A; Bramon, Elvira; Corvin, Aiden P; O'Donovan, Michael C; Stefansson, Kari; Scolnick, Edward; Purcell, Shaun; McCarroll, Steven A; Sklar, Pamela; Hultman, Christina M; Sullivan, Patrick F; Multicenter Genetic Studies of Schizophrenia Consortium
Data(s)

25/08/2013
Resumo

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
Identificador

http://pure.qub.ac.uk/portal/en/publications/genomewide-association-analysis-identifies-13-new-risk-loci-for-schizophrenia(a2910970-a09a-4ac3-bfb2-7565002450fb).html

http://dx.doi.org/10.1038/ng.2742
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Ripke , S , O'Dushlaine , C , Chambert , K , Moran , J L , Kähler , A K , Akterin , S , Bergen , S E , Collins , A L , Crowley , J J , Fromer , M , Kim , Y , Lee , S H , Magnusson , P K E , Sanchez , N , Stahl , E A , Williams , S , Wray , N R , Xia , K , Bettella , F , Borglum , A D , Bulik-Sullivan , B K , Cormican , P , Craddock , N , de Leeuw , C , Durmishi , N , Gill , M , Golimbet , V , Hamshere , M L , Holmans , P , Hougaard , D M , Kendler , K S , Lin , K , Morris , D W , Mors , O , Mortensen , P B , Neale , B M , O'Neill , F A , Owen , M J , Milovancevic , M P , Posthuma , D , Powell , J , Richards , A L , Riley , B P , Ruderfer , D , Rujescu , D , Sigurdsson , E , Silagadze , T , Smit , A B , Stefansson , H , Steinberg , S , Suvisaari , J , Tosato , S , Verhage , M , Walters , J T , Levinson , D F , Gejman , P V , Kendler , K S , Laurent , C , Mowry , B J , O'Donovan , M C , Owen , M J , Pulver , A E , Riley , B P , Schwab , S G , Wildenauer , D B , Dudbridge , F , Holmans , P , Shi , J , Albus , M , Alexander , M , Campion , D , Cohen , D , Dikeos , D , Duan , J , Eichhammer , P , Godard , S , Hansen , M , Lerer , F B , Liang , K-Y , Maier , W , Mallet , J , Nertney , D A , Nestadt , G , Norton , N , O'Neill , F A , Papadimitriou , G N , Ribble , R , Sanders , A R , Silverman , J M , Walsh , D , Williams , N M , Wormley , B , Arranz , M J , Bakker , S , Bender , S , Bramon , E , Collier , D , Crespo-Facorro , B , Hall , J , Iyegbe , C , Jablensky , A , Kahn , R S , Kalaydjieva , L , Lawrie , S , Lewis , C M , Lin , K , Linszen , D H , Mata , I , McIntosh , A , Murray , R M , Ophoff , R A , Powell , J , Rujescu , D , Van Os , J , Walshe , M , Weisbrod , M , Wiersma , D , Donnelly , P , Barroso , I , Blackwell , J M , Bramon , E , Brown , M A , Casas , J P , Corvin , A P , Deloukas , P , Duncanson , A , Jankowski , J , Markus , H S , Mathew , C G , Palmer , C N A , Plomin , R , Rautanen , A , Sawcer , S J , Trembath , R C , Viswanathan , A C , Wood , N W , Spencer , C C A , Band , G , Bellenguez , C , Freeman , C , Hellenthal , G , Giannoulatou , E , Pirinen , M , Pearson , R D , Strange , A , Su , Z , Vukcevic , D , Donnelly , P , Langford , C , Hunt , S E , Edkins , S , Gwilliam , R , Blackburn , H , Bumpstead , S J , Dronov , S , Gillman , M , Gray , E , Hammond , N , Jayakumar , A , McCann , O T , Liddle , J , Potter , S C , Ravindrarajah , R , Ricketts , M , Tashakkori-Ghanbaria , A , Waller , M J , Weston , P , Widaa , S , Whittaker , P , Barroso , I , Deloukas , P , Mathew , C G , Blackwell , J M , Brown , M A , Corvin , A P , McCarthy , M I , Spencer , C C A , Bramon , E , Corvin , A P , O'Donovan , M C , Stefansson , K , Scolnick , E , Purcell , S , McCarroll , S A , Sklar , P , Hultman , C M , Sullivan , P F & Multicenter Genetic Studies of Schizophrenia Consortium 2013 , ' Genome-wide association analysis identifies 13 new risk loci for schizophrenia ' Nature Genetics . DOI: 10.1038/ng.2742
Tipo

article
Acesso ao item digital