Localised gamma irradiation and experimental intraocular proliferation


Autoria(s): Chakravarthy, U.; Gardiner, T. A.; Maguire, C. J. F.; Archer, D. B.
Data(s)

1985

Resumo

A controlled study was undertaken to assess the effect of gamma irradiation on post-traumatic intraocular cellular proliferation. A standard perforating injury in the posterior segment of the rabbit eye was used to induce intraocular cellular proliferation and vitreo-retinal membrane formation. The site of injury was irradiated with an ophthalmic Cobalt60 applicator which provided a continuous source of gamma rays. Non-irradiated eyes developed traction retinal detachments associated with post-traumatic vitreo-retinal membranes. Irradiated eyes developed attenuated membranes or atrophic retinal scars, with the retina remaining attached. The membranes in non-irradiated eyes were highly cellular with abundant collagen, while irradiated membranes had fewer cells within a sparse collagen matrix. The episcleral fibroblasts, on autoradiographic studies appeared to be the main source of the cells that formed the proliferating tissue in both non-irradiated and irradiated eyes. In irradiated eyes both the inflammatory response and division of fibroblasts were delayed and reduced.

Identificador

http://pure.qub.ac.uk/portal/en/publications/localised-gamma-irradiation-and-experimental-intraocular-proliferation(50b7f93b-90c1-4b84-bc09-b69594613f73).html

Idioma(s)

und

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Chakravarthy , U , Gardiner , T A , Maguire , C J F & Archer , D B 1985 , ' Localised gamma irradiation and experimental intraocular proliferation ' Transactions of the ophthalmological societies of the United Kingdom , vol 104 ( Pt 7) , no. Pt 7 , pp. 792-799 .

Palavras-Chave #Animals #Cell Division/radiation effects #Collagen #Eye/pathology/radiation effects #Eye Injuries/metabolism/pathology #Fibroblasts/radiation effects #Gamma Rays #Membranes/pathology #Rabbits #Retinal Detachment/prevention & control #Sclera/metabolism #Thymidine/metabolism #Time Factors #Wounds, Penetrating/metabolism/pathology
Tipo

article