Localised gamma irradiation and experimental intraocular proliferation
Data(s) |
1985
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Resumo |
A controlled study was undertaken to assess the effect of gamma irradiation on post-traumatic intraocular cellular proliferation. A standard perforating injury in the posterior segment of the rabbit eye was used to induce intraocular cellular proliferation and vitreo-retinal membrane formation. The site of injury was irradiated with an ophthalmic Cobalt60 applicator which provided a continuous source of gamma rays. Non-irradiated eyes developed traction retinal detachments associated with post-traumatic vitreo-retinal membranes. Irradiated eyes developed attenuated membranes or atrophic retinal scars, with the retina remaining attached. The membranes in non-irradiated eyes were highly cellular with abundant collagen, while irradiated membranes had fewer cells within a sparse collagen matrix. The episcleral fibroblasts, on autoradiographic studies appeared to be the main source of the cells that formed the proliferating tissue in both non-irradiated and irradiated eyes. In irradiated eyes both the inflammatory response and division of fibroblasts were delayed and reduced. |
Identificador | |
Idioma(s) |
und |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Chakravarthy , U , Gardiner , T A , Maguire , C J F & Archer , D B 1985 , ' Localised gamma irradiation and experimental intraocular proliferation ' Transactions of the ophthalmological societies of the United Kingdom , vol 104 ( Pt 7) , no. Pt 7 , pp. 792-799 . |
Palavras-Chave | #Animals #Cell Division/radiation effects #Collagen #Eye/pathology/radiation effects #Eye Injuries/metabolism/pathology #Fibroblasts/radiation effects #Gamma Rays #Membranes/pathology #Rabbits #Retinal Detachment/prevention & control #Sclera/metabolism #Thymidine/metabolism #Time Factors #Wounds, Penetrating/metabolism/pathology |
Tipo |
article |