TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation
| Data(s) |
01/08/2013
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| Resumo |
CCN2/CTGF is an established effector of TGFß driven responses in diabetic nephropathy. We have identified an interaction between CCN2 and TGFß leading to altered phenotypic differentiation and inhibited cellular migration. Here we determine the gene expression profile associated with this phenotype and define a transcriptional basis for differential actin related gene expression and cytoskeletal function. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Faherty , N , O'Donovan , H , Kavanagh , D , Madden , S , McKay , G J , Maxwell , A P , Martin , F , Godson , C & Crean , J 2013 , ' TGFβ and CCN2/CTGF mediate actin related gene expression by differential E2F1/CREB activation ' BMC Genomics , vol 14 , no. 1 , 525 , pp. 525 . DOI: 10.1186/1471-2164-14-525 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1305 #Biotechnology #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics |
| Tipo |
article |
