Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes


Autoria(s): Song, Weiwei; Barth, Jeremy L; Yu, Yongxin; Lu, Kangmo; Dashti, Azar; Huang, Yan; Gittinger, Cynthia K; Argraves, W Scott; Lyons, Timothy J
Data(s)

01/08/2005

Resumo

Modified (oxidized and/or glycated) low-density lipoproteins (LDLs) have been implicated in retinal pericyte loss, one of the major pathologic features of early-stage diabetic retinopathy. To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression.

Identificador

http://pure.qub.ac.uk/portal/en/publications/effects-of-oxidized-and-glycated-ldl-on-gene-expression-in-human-retinal-capillary-pericytes(77b815c1-7583-47d7-9098-ee3239faa4a0).html

http://dx.doi.org/10.1167/iovs.04-1505

Idioma(s)

eng

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Song , W , Barth , J L , Yu , Y , Lu , K , Dashti , A , Huang , Y , Gittinger , C K , Argraves , W S & Lyons , T J 2005 , ' Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes ' Investigative ophthalmology & visual science , vol 46 , no. 8 , pp. 2974-82 . DOI: 10.1167/iovs.04-1505

Palavras-Chave #Adult #Capillaries #Gene Expression #Gene Expression Profiling #Humans #Lipoproteins, LDL #Oligonucleotide Array Sequence Analysis #Pericytes #Retinal Vessels #Reverse Transcriptase Polymerase Chain Reaction
Tipo

article