Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation
| Data(s) |
23/10/2009
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| Resumo |
Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Kielczewski , J L , Jarajapu , Y P R , McFarland , E L , Cai , J , Afzal , A , Li Calzi , S , Chang , K H , Lydic , T , Shaw , L C , Busik , J , Hughes , J , Cardounel , A J , Wilson , K , Lyons , T J , Boulton , M E , Mames , R N , Chan-Ling , T & Grant , M B 2009 , ' Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation ' Circulation Research , vol 105 , no. 9 , pp. 897-905 . DOI: 10.1161/CIRCRESAHA.109.199059 |
| Palavras-Chave | #Animals #Animals, Newborn #Astrocytes #Cell Adhesion Molecules #Cell Death #Cell Movement #Cell Proliferation #Cells, Cultured #Ceramides #Cerebral Arteries #Cytoprotection #Disease Models, Animal #Endothelial Cells #Female #Gene Transfer Techniques #Green Fluorescent Proteins #Humans #Infant, Newborn #Insulin-Like Growth Factor Binding Protein 3 #Male #Mesenteric Arteries #Mice #Mice, Inbred C57BL #Mice, Transgenic #Microfilament Proteins #Nitric Oxide #Nitric Oxide Synthase Type III #Phosphatidylinositol 3-Kinases #Phosphoproteins #Pregnancy #Proto-Oncogene Proteins c-akt #Rats #Rats, Sprague-Dawley #Retinal Neovascularization #Retinal Vessels #Retinopathy of Prematurity #Scavenger Receptors, Class B #Signal Transduction #Sphingomyelins #Stem Cells #Vasodilation |
| Tipo |
article |
