Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

Autoria(s): Dong, Yunzhou; Zhang, Miao; Wang, Shuangxi; Liang, Bin; Zhao, Zhengxing; Liu, Chao; Wu, Mingyuan; Choi, Hyoung Chul; Lyons, Timothy J; Zou, Ming-Hui
Data(s)

01/06/2010
Resumo

The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.
Identificador

http://pure.qub.ac.uk/portal/en/publications/activation-of-ampactivated-protein-kinase-inhibits-oxidized-ldltriggered-endoplasmic-reticulum-stress-in-vivo(4a9c3510-6303-4fe5-b7d8-970ac2a03361).html

http://dx.doi.org/10.2337/db09-1637
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Dong , Y , Zhang , M , Wang , S , Liang , B , Zhao , Z , Liu , C , Wu , M , Choi , H C , Lyons , T J & Zou , M-H 2010 , ' Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo ' Diabetes , vol 59 , no. 6 , pp. 1386-96 . DOI: 10.2337/db09-1637
Palavras-Chave #AMP-Activated Protein Kinases #Animals #Aorta #Apolipoproteins E #Cattle #Crosses, Genetic #Endoplasmic Reticulum #Endothelium, Vascular #Enzyme Activation #Gene Expression Regulation #Humans #Lipoproteins, LDL #Mice #Mice, Inbred C57BL #Mice, Knockout #RNA, Small Interfering #Umbilical Veins
Tipo

article
Acesso ao item digital