The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy
| Data(s) |
01/02/2011
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| Resumo |
Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model of diabetes. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Zhou , T , Zhou , K K , Lee , K , Gao , G , Lyons , T J , Kowluru , R & Ma , J 2011 , ' The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy ' Diabetologia , vol 54 , no. 2 , pp. 459-68 . DOI: 10.1007/s00125-010-1943-1 |
| Palavras-Chave | #Acetylcysteine #Aldehydes #Animals #Blotting, Western #Cell Line #Connective Tissue Growth Factor #Diabetic Retinopathy #Female #Humans #Hydrogen Peroxide #Immunohistochemistry #Ketocholesterols #LDL-Receptor Related Proteins #Lipid Peroxidation #Low Density Lipoprotein Receptor-Related Protein-6 #Oxidative Stress #Rats #TCF Transcription Factors #beta Catenin |
| Tipo |
article |
