EFFECT OF IMPELLER DESIGN ON PRODUCT HOMOGENIETY IN HIGH SHEAR WET GRANULATION

Design of small mixer impellers is not tailored for granulation as they are designed for a wide range of processes. The Kenwood KM070 was employed as a standard apparatus to undertake this investigation. Five different impeller designs were used, possessing different shapes and surface areas. The aim of this research was to evaluate the performances of these impellers to provide<br/>guidance on the selection and design for the purposes of granulation. Lactose granules were produced using wet granulation with water as the binder.<br/>The efficacy of respective granulates was measured by adding an optically<br/>sensitive tracer.This was used to determine powder concentrations<br/>within various regions of the granulator. It was found that impeller design influenced the homogeneity of the granules; and therefore can affect final product performance.